Textile work has traditionally been part of Tsotsil and Tseltal women’s domestic duties in the Highlands of Chiapas, Mexico. However, recent national and foreign interest in artisanal handiwork has led women from the region to start selling their work. In this commercial foray, artisanal work emerges as a trade, one that entails accommodations between women’s economic activities and their home life. While most women carry out their artisanal work at home alongside family members, the way in which they define the nature of their work and its relation to their other domestic activities varies considerably. The following video and text profile three textile artisans from the Highlands region, highlighting the distinct ways in which they organize their work and fit it together with their family life and social relations in their communities.